Celiac Disease Triggers an autoimmune war inside your body
Celiac Disease is an autoimmune disease triggered specifically by a gluten intolerance.
What is autoimmunity and what goes wrong?
Autoimmune diseases such as Celiac disease occur when the immune system begins to attack the body, and more commonly affects women. Genetic make-up and a weakened immune system due to stress, poor diet, allergies, viral or bacterial infection, oestrogen dominance, or environmental toxicity all contribute to the development of a compromised immune system which starts to attack itself. Autoimmune attacks result in severe inflammation and tissue damage.
Although each autoimmune disease involves different tissues and organs, the process that triggers the disease is the same.
Under normal conditions, the immune system is designed to protect us from bad guys(called antigens) like toxins, bacteria, viruses, cancer cells, etc. When these antigens come in contact with our body the immune system is equipped to wage war and defend our home territory.
In people with autoimmune disease, the immune system gets “confused” about what’s an antigen and what’s our own healthy body tissue, recognizing it as a threat and destroying it… it’s a tragic case of mistaken identity.
So, when people with Celiac Disease eat foods that contain gluten, their immune system is uniquely programmed to recognize it as a threat and react by damaging the tissue lining the small intestine, called villi. That’s when things get “inappropriate.” The immune system thinks it’s doing a good job keeping us safe, but it’s destroying our healthy gut lining in an all-out nuclear war.
Tiny villi lining the gut take the brunt of the attack. During normal operation, these tiny villi are responsible for absorbing nutrients from our food. But over time, these long finger-like structures get destroyed to the point of flattened out stubs.
Image source: “Celiac disease: diagnostic criteria in progress”
Do these flattened out stubs look like they can absorb nutrients and “good stuff” very well? What about protecting you from the bad guys?
Because as it Turns Out, You’re Hollow on the Inside
That’s right… from the mouth to the anus – we humans have one long hollow tube that our body considers to be part of the “outside environment.” And when we eat food, it’s actually passing through our body on the outside, while we absorb all the good stuff and let the bad stuff pass out the other end.
The gut actually plays a critical role in protecting our body from the outside environment. It’s literally functioning similar to our skin… but on the inside of the body. As food breaks down through the process of digestion in the gut, the small intestinal barrier villi absorb the good nutrients through the cells (transcellular) and protect us from undigested food, toxins, and other bad junk from getting inside. It’s just like how our skin takes in ultraviolet light from the sun while still protecting us from the outside environment.
Image Source: “Surprises from Celiac Disease”
But Celiac Disease isn’t normal circumstances. And gluten is the main reason things start to unravel with this disease…
What’s so Bad About Gluten?
Virtually all cereal grains contain toxic “prolamines,” which are proteins that are extremely tough for humans to digest. The human gut is not equipped to break down prolamines small enough to absorb any nutrients from them. These toxic prolamines give the plant a protection mechanism for their survival (since they can’t get up and run away).
Wheat contains the protein gluten, which harbours one of the worst prolamine offenders called gliadin. Researchers are finding many different parts of gluten are problematic, but gliadin has the most powerful toxic effects on the intestinal barrier and severely damages the gut lining… even in healthy people. As it turns out, these toxic effects are exponentially worse for people with the genetics for gluten sensitivity and Celiac Disease
Let’s take a closer look at how gliadin tricks the body into declaring war on itself…
Gliadin Causes Gut Inflammation
As I said, gluten proteins are really hard for healthy humans (and many other animals) to digest. It’s the Celiac genetic predisposition that creates the conditions necessary for an all-out war in the gut. Let’s say you eat your favourite bagel for breakfast and it travels down into your stomach. Your stomach will reduce the size and structure of the food, turning it into chyme, and send it along to the small intestine to break it down further and harvest the nutrients.
In the case of gluten proteins (like gliadin), they need to be broken down by the body before they’re useful, which is difficult for us humans. As these gliadin particles bounce around in the small intestine, they start causing damage (remember, they’re toxic).
Simply having undigested gliadin particles in the small intestine causes a release of IL-8,triggering the initial gut inflammation. These are the first shots fired in this war on the gut tissue…
IL-8 activates the Th1 part of the immune system (also called the “Innate Immune System”) and it’s the first layer of defines. It provides an immediate “first responder” attack on invading antigens by stimulating inflammation.
I like to think of it as the body sending ground soldiers to engage in battle and establish a perimeter against the invading enemy. The process of battling back with inflammation begins to damage the cells lining the small intestine (enterocytes).
But what happens next is the kicker…
Gliadin Sneaks Past the Intestinal Barrier
If it’s not enough that gliadin causes gut inflammation, gliadin also finds a way to get past our defences and slip behind enemy lines. Remember that the gut is lined with cells designed to let the good guys in and keep the bad guys out. In Celiac Disease, a major breakdown happens in this defines system when gliadin starts tricking its way through the wall.
Think of your gut lining like a mesh wall, with special doors to walk through if you have the secret code. The good nutrients and other smaller particles can slip right through the mesh in the wall without a problem. But larger undigested proteins like gliadin (and other bad guys) can’t get through the wall at all.
The doors along the mesh wall are called Tight Junctions, and they’re the gateway between the gut cells (enterocytes). Tight Junctions are controlled by an intricate process of signals keeping the protective balance intact and anything passing through these doors is said to be passing between the cells (paracellular). Researchers have identified a protein called zonulin in humans. Zonulin is one of those delicate signals that control the opening and closing of the tight junctions and it’s largely responsible for preventing paracellular absorption of antigens.
How do gliadin and zonulin interact?
As it turns out, gliadin is programmed with a secret code that causes zonulin levels to increase in people with the genetic pre-disposition to Celiac Disease. As zonulin levels go up, the Tight Junctions protecting the integrity of the small intestinal barrier begin to function abnormally, opening up wider… loosening the protective barrier of the gut wall. Now the gut lining starts to allow large particles into the body that aren’t supposed to be there.
And gliadin can sneak its way right through…
Here’s what that looks like on the surface of the small intestine:
Image Source: “Surprises from Celiac Disease”
When someone with Celiac Disease eats gluten, gliadin not only triggers gut inflammation, but it has a secret code that stimulates zonulin to open up the gut wall, allowing it to sneak through the doors and start infiltrating the body. At this point, gliadin can start to accumulate underneath the gut wall, assembling its forces behind enemy lines.
Gliadin Causes Leaky Gut
Remember that the immune system has already been battling gliadin outside the gut wall with an initial inflammatory process. Now, gliadin is accumulating underneath the gut wall, causing the enterocytes to release IL-15, triggering worsening inflammation inside the gut wall.
I like to think of the release of IL-15 like calling in the immune system Special Forces… sending Intraepithelial Lymphocytes (IEL’s) to the scene. These powerful IEL’s begin to damage the enterocyte cells through a more severe degree of inflammation and the war continues to get bloodier.
But that’s not all…
The IEL’s can’t match the accumulation of gliadin behind enemy lines and the inflammatory process continues to get worse. The immune system sends elite soldiers with even bigger guns called “inflammatory mediators” such as TNF and IFN that contribute to more enterocyte damage
The more severely those cells are damaged, the worse the intestinal permeability gets… and soon you’re left with full-blown leaky gut syndrome.
Now gliadin (and everything else), can freely pass through the gut wall and do as it pleases…
Image Source: “Surprises from Celiac Disease”
Leaky Gut Causes Autoimmunity
So far the immune system has been fighting gliadin with Th1 or “innate” immune system weapons. As gliadin continues to accumulate behind the gut wall, it will begin to cross-link with an enzyme called Tissue Transglutaminase (tTG) that gets released to repair damaged enterocyte cells. The cross-linking triggers a cascade of Th2 cross-reaction that wages all-out war on the enterocyte cells.
The presence of the new gliadin/tTG cross-linked compound in the body turns on the Th2 or “adaptive immune system,” which I think of like calling in secret agent snipers good at tracking, finding, and destroying the enemy.
The adaptive immune system is a powerful immune response that has the ability to coordinate much more sophisticated attacks using antibodies. Antibodies can recognize and remember specific pathogens to mount stronger attacks each time it encounters them.
Celiac Disease morphs into full-blown autoimmunity once the gut becomes leaky. The more the gut leaks, the more cross-linked gliadin/tTG becomes present, and the stronger the immune cross-reaction becomes. Autoimmunity happens when the sniper gliadin/tTG antibodies mistakenly attack the enterocyte cells, where the tTG is produced.
So, in a nutshell: the ground soldiers are fighting gliadin outside the gut wall with inflammation, the special and elite forces are fighting gliadin inside the gut wall with inflammation, and the sniper antibodies are seeking out the gliadin/tTG antigens with inflammation… all three processes leading to the destruction of the enterocyte cells lining the gut wall in their own special way. Over time, these attacks get bad enough that they completely destroy the microvilli of the intestinal lining, like a war-torn city laid to waste.
The whole process leaves those finger-like villi completely flat…
In an attempt to keep it simple, gluten causes Celiac Disease like this:
Your Body is on Fire with inflammation
Celiac Disease becomes a vicious autoimmune cycle when gluten remains in the diet, the gut remains leaky, and gliadin lights the body on fire with inflammation.
And the worst part?
The immune system is on red alert, waging all-out nuclear war with every weapon it has. This can cause untreated Celiac Disease to lead to the onset of even more autoimmune diseases.
On the surface, the process points the finger at gluten, or more specifically gliadin. It would make sense that a strict Gluten-free diet could end the entire process and break the cycle of autoimmunity
Following a Gluten-Free Diet isn’t the whole story… and getting rid of gluten alone doesn’t put the fire out.
The Health Transformer approach to Celiac disease
Meta Health Scan 5 Step Protocol
In every case of Celiac Disease or disease there is an underlying cause…something individual to each person. If at one time you didn’t have these symptoms and now do, obviously something has changed in your system in order that these symptoms have been produced. Symptoms are driven up by our body when we are out of balance and in a disease creating context. Our Symptoms are merely a sign there is an underlying root cause. To treat any Celiac disease effectively and naturally we need to address the root cause which has created the disease creating context which has led to the gluten sensitivity, and subsequent autoimmune response. . In this centre we specialize in root cause diagnosis of any health condition using our state of the art Meta Health Scan.
5 Step Protocol
1. Detect (In-Depth Evaluation & Advanced Testing)
2. Detox (Heavy Metals, Chemicals, Hydrocarbons, Bleaches, EMF)
3. Eliminate (Pathogens…virus, post virus, bacteria, parasites, fungi)
4. Rebuild (Tissues & Pathways)
5. Rebalance organs (Gut, kidneys, liver, etc.)
The 5 Steps to Restoring Health Protocol had been developed following many years of research and experience and utilizes food, nutritional supplements, herbal and energetic formula
The Meta Health Scan is carried out utilizing the amazing diagnostic ability of Clinical Kinesiology. It is reliable, accurate and reproducible. The scan will reveal the imbalances unique to your body, and how these are affecting you. The scan reveals such issues as;
• endogenous bio-toxicity,
• nutrient imbalances or deficiencies,
• sub-clinical infections,
• Allergies and food sensitivities.
• Energetic organ imbalances,
• hormone imbalance,
• Leaky gut.
Abnormality in any of these areas will easily be picked up during the Health Scan. We also examine your entire lifestyle, sleep quality and any emotional/psychological contributors to your condition.
In-Depth Consultation regarding your results.
Once this information is gathered we offer you an in-depth consultation to discuss your results, during which we discuss what has been revealed by the scan, where and how this has arisen, and how to remove or transform it, and reboot your system. I believe it is very important for each person to understand what has been going on in their body, how the condition has developed, and how to unravel and resolve it naturally. My intention is not just to teach you about your condition, but more importantly to empower you with understanding in order that you are able to take back control of your health.
Individually tailored Treatment Plan
Together we create an individualized tailored treatment plan for you. This may include some or all of there: a gentle detoxification protocol, dietary changes, specific supplements, life style changes, exercise, etc tailored to your specific needs. In the majority of cases treatment can be implemented by you at home without the need for repeated visits to the centre; however Health Coaching and support is built in to this package to assist you through your treatment.
Once on the prescribed treatment, some clients choose to support their system with other therapies toastiest healing. This is not essential but will speed up your progress. These include;
all of which are on offer at this centre.
I am delighted to be able to report that the results our client’s achieve with this approach are outstanding and lasting in the vast majority of cases.
ou have suspected food allergies, digestive problems, chronic diarrhea, bowel problems, skin issues, memory issues, fatigue, aches and pains, are or just feeling warn out, it is most likely that you are toxic. You can totally reverse your disease process by undertaking the correct detox for the type of toxins present in your system. To determine which toxins are present and poisoning you, book a Health Scan in this clinic. Our test is accurate and our results are excellent. phone 02866328200 and speak to Linda.