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NaturalTreatment for Bacterial Dysbiosis

NaturalTreatment for Bacterial Dysbiosis

NaturalTreatment for Bacterial Dysbiosis: Overview

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Friendly bacteria are critically important for the health of our digestive and immune systems, for their detoxification and hormone-regulating capabilities, and for nutrient formation and absorption.
Altered microbial ecology in the gut may produce disease and dysfunction because of the the intense metabolic activity and the antigenic nature of bacterial flora.  Bacterial enzymes can degrade pancreatic enzymes, damage the intestinal absorptive surface, release toxins that had previously been bound by conjugation and alter the intestinal milieu in numerous ways, some of which can be easily measured in a properly collected sample of stool.

Gut bacterial disbiosis is now considered to be at the source of most chronic and serious disease.   It is certainly implicated int the following: IBS leaky gut, indigestion, acid re flux, allergy, food intolerance, autoimmune disorders, chronic inflammatory conditions, chronic disease, cancer


Causes and Development
Based on available research and clinical data, there are four general causes of intestinal dysbiosis: putrefaction, fermentation, deficiency and sensitization.
1. Putrefaction. Putrefaction dysbiosis results from diets high in fat and animal flesh and low ininsoluble fiber.  This type of diet produces an increased concentration of Bacteroidesspecies and a decreased concentration of Bifidobacteria in the stool.  It increases bile flow and induces bacterial urease activity.  The change in composition of the gut flora leads to an increase in bacterial enzymes which, amongst other things, increases cancer causing substances and interferes with the body's hormones.  As there is a decrease in friendlybacteria, the production of short-chain fatty acids and other beneficial nutrients is decreased.  There is also an increase in ammonia which can have negative effects on numerous bodily functions.  Research has implicated this type of dysbiosis in contributing tocolon cancer and breast cancer.
2. Fermentation / Small Bowel Bacterial Overgrowth (SBBO). This is a condition ofcarbohydrate intolerance induced by overgrowth of bacteria in the stomach, small intestineand beginning of the large intestine.  Bacterial overgrowth here is promoted byhypochlorhydria, by stasis due to abnormal bowel motility, physical/surgical abnormalities, by immune deficiency or by malnutrition.  Gastric bacterial overgrowth increases the risk of systemic infection and the sufferer develops an intolerance to carbohydrate.  Any carbohydrate ingested is fermented by the bacteria and results in production of toxic waste products.
Carbohydrate intolerance may be the only symptom of bacterial overgrowth, making it indistinguishable from intestinal candidiasis; in either case dietary sugars can be fermented to produce endogenous ethanol.  Chronic exposure of the small bowel to ethanol may itself impair intestinal permeability.  British physicians working with the gut-fermentation syndrome have tentatively concluded, based on treatment results, that the majority of cases are due toyeast overgrowth and about 20% are bacterial in origin.  The symptoms include abdominaldistension, carbohydrate intolerance, fatigue and impaired mental function.
The risk factors for SBBO include those for yeast overgrowth and also: Insufficient stomach acid; Abnormal stool motility; Strictures; Surgery; Immune deficiency; Malnutrition.  SBBO has been implicated in gastric cancer and can cause acidosis (where the body becomes too acidic) due to increased production of lactic acid.
3. Deficiency. Exposure to antibiotics or a diet depleted of soluble fiber may create an absolute deficiency of normal fecal flora, including Bifidobacteria, Lactobacillus and E.  Coli.  Direct evidence of this condition is seen on stool culture when concentrations ofLactobacillus or E.  Coli are reduced.  This condition has been described in patients withirritable bowel syndrome and food intolerance.  Deficiency and putrefaction dysbiosis are complementary conditions which often occur at the same time and call for the same treatment regime.
4. Sensitization. Aggravation of abnormal immune responses to components of the normal intestinal microflora may contribute to the development of inflammatory bowel disease, spinal arthritis, other connective tissue disease and skin disorders such as psoriasis oracne.  The responsible bacterial components include toxins which can cross-react with human tissues.

Diagnosis and testing

In this practice we test for bacterial dysbiosis with Autonomic Response Testing using Clinical Kinesiology.   It is non-invasive and accurate.


Effective treatment of dysbiosis with diet, antimicrobial substances and bacterial replacement or support must distinguish among patterns of dysbiosis.  The failure of common approaches utilizing fiber and Lactobacilli alone is a strong indication of small bowel bacterial overgrowth, a challenging disorder which demands a radically different approach from a dysbiosis of the large intestine.  Stool examination generally reflects large bowel bacterial colonization.  Other testing means are required for uncovering bacterial overgrowth in the small intestine.
In cases of Putrefaction Dysbiosis, the alterations in bacterial population dynamics which result from this diet are measured by an increase in stool pH (partly caused by elevated ammonia production) and in bile or urobilinogen and possibly by a decrease in short chain fatty acids, especially in butyrate.


Treatment and Prevention
Putrefaction dysbiosis is usually managed with a diet high in both soluble and insoluble fiberand low in saturated fat and animal protein.  These dietary changes work to lower the concentrations of Bacteroides and increase concentrations of lactic acid-producing bacteria(Bifidobacteria, Lactobacillus and lactic acid streptococci) in the colon.
Supplementing the diet with defined sources of fiber can have variable effects on colonicdysbiosis.  Insoluble fiber decreases bacterial concentration and microbial enzyme activity. Soluble fiber, on the other hand, tends to elevate bacterial concentration and enzyme activity, at the same time raising the levels of beneficial short chain fatty acids.  This disparity may explain the superior effect of insoluble fiber in the prevention of colon cancer.
Dairy products have a variable effect and fermented dairy foods such as fresh yogurt are occasionally helpful.  Experimentation and careful observation of symptoms may be required to determine whether these foods will help or harm.
Fermentation dysbiosis, conversely, can cause starch and soluble fiber to exacerbate the abnormal gut ecology.  When the upper small bowel is involved, simple sugars are also contraindicated.  A diet free of cereal grains and added sugar is generally the most helpful.  Fruit, fat and starchy vegetables are tolerated to variable degree in different cases.  Oligosaccharides found in some vegetables, carrots in particular, inhibit the binding of enterobacteria to the intestinalmucosa.

Complications
Bacterial antigens may elicit dysfunctional immune responses which contribute to autoimmune diseases of the bowel and of connective tissue.


Signs, symptoms & indicators of Bacterial Dysbiosis:


Symptoms - Abdomen
Occasional slight bloating may be a sign or symptom of Bacterial Dysbiosis
Symptoms - Bowel Movements
Very frequent stools is often a sign or symptom of Bacterial Dysbiosis
Chronic diarrhea is often a sign or symptom of Bacterial Dysbiosis, Recent onset/chronic diarrhea or diarrhea for 1-3 months
Counter-indicators
No significant diarrhea often contraindicates Bacterial


Symptoms - Food 
Poor tolerance/intolerance of sugars is often a sign or symptom of Bacterial Dysbiosis


Symptoms - Gas
History of/current GI infection/parasite is often a sign or symptom of Bacterial
General flatulence is often a sign or symptom of Bacterial Dysbiosis
(Occasional/frequent) rotten egg burps is often a sign or symptom of Bacterial Dysbiosis
(Frequent) meal-related bloating is often a sign or symptom of Bacterial Dysbiosis(


Symptoms - General
Constant fatigue may be a sign or symptom of Bacterial Dysbiosis


Conditions that suggest Bacterial Dysbiosis:


Allergy

Allergy to Foods (Hidden) often suggests Bacterial Dysbiosis


Autoimmune
Ankylosing Spondylitis strongly suggests Bacterial Dysbiosis

Intestinal overgrowth of an organism called Klebsiella plays a role in determining who is affected by ankylosing spondylitis and how severely.  Research by doctors at King's College has uncovered a tissue similarity between this organism and the spine.  In an autoimmune reaction to excessive amounts of Klebsiella, the immune system attacks the spine.  Controlling this dysbiosis by diet reduces symptoms of the disease


Crohns Disease often suggests Bacterial Dysbiosis
During the early 1980s, exaggerated immunologic responses to components of the normal fecal flora were proposed as possible mechanisms behind inflammatory bowel disease.  Little progress has been made in confirming or disproving this theory, although bacterial overgrowth of the jejunum has been found in 30% of patients hospitalized for Crohn's disease, in which it contributes to diarrhea and malabsorption.  The demonstration of increased intestinal permeability in patients with active Crohn's disease and in healthy first degree relatives suggests the existence of a preexisting abnormality, such as dysbiosis, that allows an exaggerated immune response to normal gut contents to occur.

Elimination diets can induce remission in Crohn's disease as effectively as prednisone.  The primary bacteriologic effect of elemental diets is to lower the concentration of Lactobacilli in the stool drastically without altering levels of other bacteria.


Autoimmune Tendency often suggests Bacterial Dysbiosis


Circulation
Megaloblastic Anemia / Pernicious Anemia often suggests Bacterial Dysbiosis

Abnormal bacterial populations may consume cobalamin, contributing to B12 deficiency states and resulting in megaloblastic anemia.


Digestion
IBS (Irritable Bowel Syndrome) strongly suggests Bacterial Dysbiosis)
Some bacterial infections of the small bowel increase passive intestinal permeability.  IBS has been studied in patients with diarrhea, cramps and specific food intolerances.  Abnormal fecal flora has been a consistent finding, with a decrease in the ratio of anaerobes to aerobes, apparently due to a deficiency of anaerobic flora.  Previous exposure to antibiotics – metronidazole in particular – was associated with the development of this disorder.


Increased Intestinal Permeability / Leaky Gut may suggest Bacterial Dysbiosis
It is likely that both yeast and bacterial overgrowth commonly occur together; overgrowth of either can lead to Leaky Gut Syndrome.


Musculo-Skeletal
Rheumatoid Arthritis often suggests Bacterial Dysbiosis

Immunologic responses to gut flora have been advanced by several authors as being important causative factors of inflammatory joint diseases.  It is well-known that reactive arthritis can be activated by intestinal infections with Yersinia, Salmonella and other enterobacteria.  In some cases bacterial antigens have been found in synovial cells and may enter the circulation because of the increased intestinal permeability associated with the intestinal infection.  Increased intestinal permeability and immune responses to bacterial debris may cause other types of inflammatory joint disease as well


Skin-Hair-Nails
Eczema strongly suggests Bacterial Dysbiosis
Fecal and duodenal flora in patients with atopic eczema have been studied.  Evidence of small bowel dysbiosis and subtle malabsorption phenomena was found in the majority of cases.


Adult Acne often suggests Bacterial Dysbiosis


Psoriasis often suggests Bacterial Dysbiosis


Tumors, Malignant
Breast Cancer may suggest Bacterial Dysbiosis
Epidemiologic and experimental data implicate putrefactive dysbiosis in the development of colon cancer and breast cancer.  A putrefaction dysbiosis is accompanied by an increase in fecal concentrations of various bacterial enzymes which metabolize bile acids to tumor promoters and deconjugate excreted estrogens, raising the plasma estrogen level.
Colon Cancer may suggest Bacterial Dysbiosis
A putrefaction dysbiosis is accompanied by an increase in fecal concentrations of various bacterial enzymes which metabolize bile acids to tumor promoters.


Risk factors for Bacterial Dysbiosis:
Digestion Hydrochloric Acid Deficiency
Parasites
Parasite Infection often increases risk of Bacterial Dysbiosis
Small bowel parasites may predispose a person to bacterial overgrowth in the small intestine.
Supplements and Medications
PPI antacid use often increases risk of Bacterial Dysbiosis
Research suggests that gastritis and ulcers are triggered by bacterial overgrowth, rather than by stomach acidity.  Long-term treatment of patients with potent acid blockers (proton pump inhibitors) which produce a more alkaline environment that is unfriendly to acid-tolerant bacteria such as Helicobacter pylori, may actually allow the overgrowth of other types of bacteria in the stomach, including Lactobacillus, Enterobacter, Staphylococcus and Propionibacterium which can result in inflammation, gastritis and ulceration.  [Gastroenterology, Jan 2002]
Tetracycline use often increases risk of Bacterial Dysbiosis
Broad-spectrum antibiotic use often increases risk of Bacterial Dysbiosis

One of the ways to help reestablish a balanced bacterial population in the GI tract is the use of probiotics.  There are many products on the market containing a variety of organisms and a general approach could be taken using a broad spectrum probiotic formula.  However, a better method is to discover the type of imbalance by testing and then supplementing those specific bacteria that are needed.  Bringing these normally-occurring bacteria into balance will help prevent the overgrowth of more pathogenic organisms.

Bifidobacteria are the predominant lactic acid bacteria of the colon with a concentration that is 1000 times higher than Lactobacilli.  Administration of Bifidobacterium brevum to humans and animals reduces fecal concentrations of Clostridia and Enterobacter species, ammonia, and toxin-releasing bacterial enzymes including beta-glucuronidase and tryptophanase.  Bacillus laterosporus, a novel organism classified as non-pathogenic to humans, produces unique metabolites with antibiotic, antitumor and immune modulating activity.  This organism is available as a food supplement in the United States.  It has been found to be an effective adjunctive treatment for control of symptoms associated with small bowel dysbiosis in a number of patients.
Fructose-containing oligosaccharides (FOS), found in vegetables like onion and asparagus, have been developed as a food supplement for raising stool levels of Bifidobacteria and lowering stool pH.


Health problems rarely occur in isolation or for obvious reasons   Your body is a highly complex, interconnected system.  Instead of guessing at what might be wrong, let us help you discover what is really going on inside your body based on the many clues it is giving.
If you are experiencing any health issue and would like to address the root cause rather than manage the symptoms with medication, this is exactly what we specialize in and have had huge success with a wide range of health issues over the past 35 years.   Consultations are available on line via skype.     For further information please call Linda on 02866328200 or email me on info@lindaburke.co.uk